SNAP-annotated 5mC-DNA-protein interactions: PDB entry 5t01

PDB-id

5t01; DSSR-derived features in text and JSON formats; DNAproDB

Class

transcription regulator-DNA

Method

X-ray (1.89 Å)

Summary

Human c-jun DNA binding domain homodimer in complex with methylated DNA

Reference

Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X (2017): "Methyl-dependent and spatial-specific DNA recognition by the orthologous transcription factors human AP-1 and Epstein-Barr virus Zta." Nucleic Acids Res., 45, 2503-2515. doi: 10.1093/nar/gkx057.

Abstract

 

• The contacts include paired nucleotides (mostly a G in Watson-Crick G-C pairing) and amino-acids within a 4.5-Å distance cutoff to base atoms of 5mC.
• The structure is oriented in the base reference frame of 5mC, allowing for easy comparison and direct superimposition between entries.
• The black sphere (•) denotes the 5-methyl carbon atom in 5mC.