SNAP-annotated 5mC-DNA-protein interactions: PDB entry 6w8w

PDB-id

6w8w; DSSR-derived features in text and JSON formats; DNAproDB

Class

transferase-DNA

Method

X-ray (3.0 Å)

Summary

Crystal structure of mouse dnmt1 in complex with ccg DNA

Reference

Adam S, Anteneh H, Hornisch M, Wagner V, Lu J, Radde NE, Bashtrykov P, Song J, Jeltsch A (2020): "DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context." Nat Commun.

Abstract

 

• The contacts include paired nucleotides (mostly a G in Watson-Crick G-C pairing) and amino-acids within a 4.5-Å distance cutoff to base atoms of 5mC.
• The structure is oriented in the base reference frame of 5mC, allowing for easy comparison and direct superimposition between entries.
• The black sphere (•) denotes the 5-methyl carbon atom in 5mC.