5mC-DNA-protein interactions for PDB entry 6w8w

Summary information and primary citation

PDB-id: 6w8w; SNAP-derived features in text and JSON formats; DNAproDB
Class: transferase-DNA
Method: X-ray (3.0 Å)
Summary: Crystal structure of mouse dnmt1 in complex with ccg DNA
Reference: Adam S, Anteneh H, Hornisch M, Wagner V, Lu J, Radde NE, Bashtrykov P, Song J, Jeltsch A (2020): "DNMT1 activity, base flipping mechanism and genome-wide DNA methylation are regulated by the DNA sequence context." Nat Commun.
Abstract

The contacts include paired nucleotides (mostly a G in Watson-Crick G-C pairing), and amino-acids within a 4.5-A distance cutoff to base atoms of 5mC.
The structure is oriented in the base reference frame of 5mC, allowing for easy comparison and direct superimposition between entries.
The black sphere (•) denotes the 5-methyl carbon atom in 5mC.

No. 1 C.5CM6: `stacking-with-A.TRP1512 is-WC-paired is-in-duplex [+]:Ac./.GT`

No. 2 E.5CM6: `stacking-with-B.TRP1512 is-WC-paired is-in-duplex [+]:Ac./.GT`