SNAP output for PDB entry 1awc [SNAP web server]

PDB-id

1awc; SNAP-derived features in text and JSON formats; DNAproDB

Class

transcription-DNA

Method

X-ray (2.15 Å)

Summary

Mouse gabp alpha-beta domain bound to DNA

Reference

Batchelor AH, Piper DE, de la Brousse FC, McKnight SL, Wolberger C (1998): "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA." Science, 279, 1037-1041. doi: 10.1126/science.279.5353.1037.

Abstract

GA-binding protein (GABP) is a transcriptional regulator composed of two structurally dissimilar subunits. The alpha subunit contains a DNA-binding domain that is a member of the ETS family, whereas the beta subunit contains a series of ankyrin repeats. The crystal structure of a ternary complex containing a GABPalpha/beta ETS domain-ankyrin repeat heterodimer bound to DNA was determined at 2. 15 angstrom resolution. The structure shows how an ETS domain protein can recruit a partner protein using both the ETS domain and a carboxyl-terminal extension and provides a view of an extensive protein-protein interface formed by a set of ankyrin repeats. The structure also reveals how the GABPalpha ETS domain binds to its core GGA DNA-recognition motif.