Summary information and primary citation
- PDB-id
- 1cdw; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (1.9 Å)
- Summary
- Human tbp core domain complexed with DNA
- Reference
- Nikolov DB, Chen H, Halay ED, Hoffman A, Roeder RG, Burley SK (1996): "Crystal structure of a human TATA box-binding protein/TATA element complex." Proc.Natl.Acad.Sci.USA, 93, 4862-4867. doi: 10.1073/pnas.93.10.4862.
- Abstract
- The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.
