SNAP output for PDB entry 1ecr [SNAP web server]

PDB-id

1ecr; SNAP-derived features in text and JSON formats; DNAproDB

Class

replication-DNA

Method

X-ray (2.7 Å)

Summary

Escherichia coli replication terminator protein (tus) complexed with DNA

Reference

Kamada K, Horiuchi T, Ohsumi K, Shimamoto N, Morikawa K (1996): "Structure of a replication-terminator protein complexed with DNA." Nature, 383, 598-603. doi: 10.1038/383598a0.

Abstract

The crystal structure of the Escherichia coli replication-terminator protein (Tus) bound to terminus-site (Ter) DNA has been determined at 2.7 A resolution. The Tus protein folds into a previously undescribed architecture divided into two domains by a central basic cleft. This cleft accommodates locally deformed B-form Ter DNA and makes extensive contacts with the major groove, mainly through two interdomain beta-strands. The unusual structural features of this complex may explain how the replication fork is halted in only one direction.