Summary information and primary citation

PDB-id
1l1t; SNAP-derived features in text and JSON formats; DNAproDB
Class
hydrolase-DNA
Method
X-ray (1.8 Å)
Summary
Mutm (fpg) bound to abasic-site containing DNA
Reference
Fromme JC, Verdine GL (2002): "Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutM." Nat.Struct.Biol., 9, 544-552.
Abstract
MutM is a bacterial 8-oxoguanine glycosylase responsible for initiating base-excision repair of oxidized guanine residues in DNA. Here we report five different crystal structures of MutM-DNA complexes that represent different steps of the repair reaction cascade catalyzed by the protein and also differ in the identity of the base opposite the lesion (the 'estranged' base). These structures reveal that the MutM active site performs the multiple steps of base-excision and 3' and 5' nicking with minimal rearrangement of the DNA backbone.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js