Summary information and primary citation
- PDB-id
- 1mtl; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- hydrolase-DNA
- Method
- X-ray (2.8 Å)
- Summary
- Non-productive mug-DNA complex
- Reference
- Barrett TE, Savva R, Barlow T, Brown T, Jiricny J, Pearl LH (1998): "Structure of a DNA base-excision product resembling a cisplatin inter-strand adduct." Nat.Struct.Biol., 5, 697-701. doi: 10.1038/1394.
- Abstract
- Base-excision of a self-complementary oligonucleotide with central G:T mismatches by the G:T/U-specific mismatch DNA glycosylase (MUG), generates an unusual DNA structure which is remarkably similar in conformation to an interstrand DNA adduct of the anti-tumor drug cis-diamminedichloroplatinum. The abasic sugars generated by excision of the mismatched thymines are extruded from the double-helix, and the 'widowed' deoxyguanosines rotate so that their N7 and O6 groups protrude into the minor groove of the duplex and restack in an interleaved intercalative geometry, generating a kink in the helix axis.
