Summary information and primary citation
- PDB-id
- 1pzu; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (3.1 Å)
- Summary
- An asymmetric nfat1-rhr homodimer on a pseudo-palindromic, kappa-b site
- Reference
- Jin L, Sliz P, Chen L, Macian F, Rao A, Hogan PG, Harrison SC (2003): "An asymmetric NFAT1 dimer on a pseudo-palindromic KB-like DNA site." Nat.Struct.Biol., 10, 807-811. doi: 10.1038/nsb975.
- Abstract
- The crystal structure of the NFAT1 Rel homology region (RHR) bound to a pseudo-palindromic DNA site reveals an asymmetric dimer interaction between the RHR-C domains, unrelated to the contact seen in Rel dimers such as NF kappa B. Binding studies with a form of the NFAT1 RHR defective in the dimer contact show loss of cooperativity and demonstrate that the same interaction is present in solution. The structure we have determined may correspond to a functional NFAT binding mode at palindromic sites of genes induced during the anergic response to weak TCR signaling.
