Summary information and primary citation
- PDB-id
- 1sfo; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transcription-DNA-RNA hybrid
- Method
- X-ray (3.61 Å)
- Summary
- RNA polymerase ii strand separated elongation complex
- Reference
- Westover KD, Bushnell DA, Kornberg RD (2004): "Structural Basis of Transcription: Separation of RNA from DNA by RNA Polymerase II." Science, 303, 1014-1016. doi: 10.1126/science.1090839.
- Abstract
- The structure of an RNA polymerase II-transcribing complex has been determined in the posttranslocation state, with a vacancy at the growing end of the RNA-DNA hybrid helix. At the opposite end of the hybrid helix, the RNA separates from the template DNA. This separation of nucleic acid strands is brought about by interaction with a set of proteins loops in a strand/loop network. Formation of the network must occur in the transition from abortive initiation to promoter escape.
