Summary information and primary citation
- PDB-id
- 1skn; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transcription-DNA
- Method
- X-ray (2.5 Å)
- Summary
- The binding domain of skn-1 in complex with DNA: a new DNA-binding motif
- Reference
- Rupert PB, Daughdrill GW, Bowerman B, Matthews BW (1998): "A new DNA-binding motif in the Skn-1 binding domain-DNA complex." Nat.Struct.Biol., 5, 484-491. doi: 10.1038/nsb0698-484.
- Abstract
- The DNA-binding domain of Skn-1, a developmental transcription factor that specifies mesoderm in C. elegans, is shown by X-ray crystallography to have a novel fold in which a compact, monomeric, four-helix unit organizes two DNA-contact elements. At the C-terminus, a helix extends from the domain to occupy the major groove of DNA in a manner similar to bZip proteins. Skn-1, however, lacks the leucine zipper found in all bZips. Additional contacts with the DNA are made by a short basic segment at the N-terminus of the domain, reminiscent of the 'homeodomain arm'.
