SNAP output for PDB entry 1srs [SNAP web server]

PDB-id

1srs; SNAP-derived features in text and JSON formats; DNAproDB

Class

transcription-DNA

Method

X-ray (3.2 Å)

Summary

Serum response factor (srf) core complexed with specific sre DNA

Reference

Pellegrini L, Tan S, Richmond TJ (1995): "Structure of serum response factor core bound to DNA." Nature, 376, 490-498. doi: 10.1038/376490a0.

Abstract

The human serum response factor is a transcription factor belonging to the MADS domain protein family with members characterized from the plant and animal kingdoms. The X-ray crystal structure of the serum response factor core in a specific-recognition DNA complex shows that the functions of DNA binding, dimerization and accessory-factor interaction are compactly integrated into a novel protein unit. The intrinsic and induced conformation of the serum response element DNA is the principal DNA feature recognized in the specific complex.