Summary information and primary citation

PDB-id
1t2s; SNAP-derived features in text and JSON formats; DNAproDB
Class
nucleic acid binding protein-DNA
Method
NMR
Summary
Structural basis for 3' end recognition of nucleic acids by the drosophila argonaute 2 paz domain
Reference
Lingel A, Simon B, Izaurralde E, Sattler M (2004): "Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain." Nat.Struct.Mol.Biol., 11, 576-577. doi: 10.1038/nsmb777.
Abstract
We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js