Summary information and primary citation
- PDB-id
- 1t2s; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- nucleic acid binding protein-DNA
- Method
- NMR
- Summary
- Structural basis for 3' end recognition of nucleic acids by the drosophila argonaute 2 paz domain
- Reference
- Lingel A, Simon B, Izaurralde E, Sattler M (2004): "Nucleic acid 3'-end recognition by the Argonaute2 PAZ domain." Nat.Struct.Mol.Biol., 11, 576-577. doi: 10.1038/nsmb777.
- Abstract
- We describe the solution structures of the Argonaute2 PAZ domain bound to RNA and DNA oligonucleotides. The structures reveal a unique mode of single-stranded nucleic acid binding in which the two 3'-terminal nucleotides are buried in a hydrophobic cleft. We propose that the PAZ domain contributes to the specific recognition of siRNAs by providing a binding pocket for their characteristic two-nucleotide 3' overhangs.
