Summary information and primary citation

PDB-id
1vol; SNAP-derived features in text and JSON formats; DNAproDB
Class
transcription-DNA
Method
X-ray (2.7 Å)
Summary
Tfiib (human core domain)-tbp (a.thaliana)-tata element ternary complex
Reference
Nikolov DB, Chen H, Halay ED, Usheva AA, Hisatake K, Lee DK, Roeder RG, Burley SK (1995): "Crystal structure of a TFIIB-TBP-TATA-element ternary complex." Nature, 377, 119-128. doi: 10.1038/377119a0.
Abstract
The crystal structure of the transcription factor IIB (TFIIB)/TATA box-binding protein (TBP)/TATA-element ternary complex is described at 2.7 A resolution. Core TFIIB resembles cyclin A, and recognizes the preformed TBP-DNA complex through protein-protein and protein-DNA interactions. The amino-terminal domain of core TFIIB forms the downstream surface of the ternary complex, where it could fix the transcription start site. The remaining surfaces of TBP and the TFIIB can interact with TBP-associated factors, other class II initiation factors, and transcriptional activators and coactivators.

Cartoon-block schematics in six views (download the tarball)

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