SNAP output for PDB entry 1vtn [SNAP web server]

PDB-id

1vtn; SNAP-derived features in text and JSON formats; DNAproDB

Class

transcription-DNA

Method

X-ray (2.5 Å)

Summary

Co-crystal structure of the hnf-3-fork head DNA-recognition motif resembles histone h5

Reference

Clark KL, Halay ED, Lai E, Burley SK (1993): "Co-Crystal Structure of the HNF-3/Fork Head DNA-Recognition Motif Resembles Histone H5." Nature, 364, 412-420. doi: 10.1038/364412a0.

Abstract

The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed with DNA has been determined by X-ray crystallography at 2.5 A resolution. This alpha/beta protein binds B-DNA as a monomer, through interactions with the DNA backbone and through both direct and water-mediated major and minor groove base contacts, inducing a 13 degrees bend. The transcription factor fold is very similar to the structure of histone H5. In its amino-terminal half, three alpha-helices adopt a compact structure that presents the third helix to the major groove. The remainder of the protein includes a twisted, antiparallel beta-structure and random coil that interacts with the minor groove.