Summary information and primary citation

PDB-id
1vto; SNAP-derived features in text and JSON formats; DNAproDB
Class
transcription-DNA
Method
X-ray (1.9 Å)
Summary
1.9 Å resolution refined structure of tbp recognizing the minor groove of tataaaag
Reference
Kim JL, Burley SK (1994): "1.9 A Resolution Refined Structure of TBP Recognizing the Minor Groove of TATAAAAG." Nat.Struct.Biol., 1, 638-653.
Abstract
The three-dimensional structure of a TATA box-binding protein (TBP) from Arabidopsis thaliana complexed with a fourteen base pair oligonucleotide bearing the Adenovirus major late promoter TATA element has been refined at 1.9 A resolution, giving a final crystallographic R-factor of 19.4%. Binding of the monomeric, saddle-shaped alpha/beta protein induces an unprecedented conformational change in the DNA. A detailed structural and functional analysis of this unusual protein-DNA complex is presented, with particular emphasis on the mechanisms of DNA deformation, TATA element recognition, and preinitiation complex assembly.

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