SNAP output for PDB entry 2b6g [SNAP web server]

PDB-id

2b6g; SNAP-derived features in text and JSON formats; DNAproDB

Class

RNA binding protein

Method

NMR

Summary

RNA recognition by the vts1 sam domain

Reference

Johnson PE, Donaldson LW (2006): "RNA recognition by the Vts1p SAM domain." Nat.Struct.Mol.Biol., 13, 177-178. doi: 10.1038/nsmb1039.

Abstract

The putative yeast post-transcriptional regulator Vts1p and its related protein Smaug, from Drosophila melanogaster, each use a sterile alpha motif (SAM) domain to bind an RNA hairpin termed the Smaug recognition element (SRE). Here, we present the NMR structures of the Vts1p-SRE complex and the free SRE. Structural highlights include the direct recognition of a guanine base and the formation or stabilization of a base pair in the SRE loop.