SNAP output for PDB entry 2bop [SNAP web server]

PDB-id

2bop; SNAP-derived features in text and JSON formats; DNAproDB

Class

transcription-DNA

Method

X-ray (1.7 Å)

Summary

Crystal structure at 1.7 angstroms of the bovine papillomavirus-1 e2 DNA-binding domain bound to its DNA target

Reference

Hegde RS, Grossman SR, Laimins LA, Sigler PB (1992): "Crystal structure at 1.7 A of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target." Nature, 359, 505-512. doi: 10.1038/359505a0.

Abstract

The dominant transcriptional regulator of the papillomaviruses, E2, binds to its specific DNA target through a previously unobserved dimeric antiparallel beta-barrel. The DNA is severely but smoothly bent over the barrel by the interaction of successive major grooves with a pair of symmetrically disposed alpha-helices. The specific interface is an 'interwoven' network of interactions where the identifying base pairs of the target contact more than one amino-acid side chain and the discriminating amino acids interact with more than one base pair.