Summary information and primary citation
- PDB-id
- 2bzf; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- DNA binding protein
- Method
- X-ray (2.87 Å)
- Summary
- Structural basis for DNA bridging by barrier-to-autointegration factor (baf)
- Reference
- Bradley CM, Ronning DR, Ghirlando R, Craigie R, Dyda F (2005): "Structural Basis for DNA Bridging by Barrier-to-Autointegration Factor." Nat.Struct.Mol.Biol., 12, 935. doi: 10.1038/NSMB989.
- Abstract
- The ability of barrier-to-autointegration factor (BAF) to bind and bridge DNA in a sequence-independent manner is crucial for its role in retroviral integration and a variety of cellular processes. To better understand this behavior, we solved the crystal structure of BAF bound to DNA. The structure reveals that BAF bridges DNA using two pairs of helix-hairpin-helix motifs located on opposite surfaces of the BAF dimer without changing its conformation.
