SNAP output for PDB entry 2fk6 [SNAP web server]

PDB-id

2fk6; SNAP-derived features in text and JSON formats; DNAproDB

Class

hydrolase-RNA

Method

X-ray (2.9 Å)

Summary

Crystal structure of rnase z-trna(thr) complex

Reference

Li de la Sierra-Gallay I, Mathy N, Pellegrini O, Condon C (2006): "Structure of the ubiquitous 3' processing enzyme RNase Z bound to transfer RNA." Nat.Struct.Mol.Biol., 13, 376-377. doi: 10.1038/nsmb1066.

Abstract

The highly conserved ribonuclease RNase Z catalyzes the endonucleolytic removal of the 3' extension of the majority of tRNA precursors. Here we present the structure of the complex between Bacillus subtilis RNase Z and tRNA(Thr), the first structure of a ribonucleolytic processing enzyme bound to tRNA. Binding of tRNA to RNase Z causes conformational changes in both partners to promote reorganization of the catalytic site and tRNA cleavage.