SNAP output for PDB entry 2gic [SNAP web server]

PDB-id

2gic; SNAP-derived features in text and JSON formats; DNAproDB

Class

virus-viral protein-RNA

Method

X-ray (2.92 Å)

Summary

Crystal structure of a vesicular stomatitis virus nucleocapsid-RNA complex

Reference

Green TJ, Zhang X, Wertz GW, Luo M (2006): "Structure of the vesicular stomatitis virus nucleoprotein-RNA complex unveils how the RNA is sequestered." Science, 313, 357-360. doi: 10.1126/science.1126953.

Abstract

Vesicular stomatitis virus is a negative-stranded RNA virus. Its nucleoprotein (N) binds the viral genomic RNA and is involved in multiple functions including transcription, replication, and assembly. We have determined a 2.9 angstrom structure of a complex containing 10 molecules of the N protein and 90 bases of RNA. The RNA is tightly sequestered in a cavity at the interface between two lobes of the N protein. This serves to protect the RNA in the absence of polynucleotide synthesis. For the RNA to be accessed, some conformational change in the N protein should be necessary.