SNAP output for PDB entry 2qux [SNAP web server]

PDB-id

2qux; SNAP-derived features in text and JSON formats; DNAproDB

Class

structural protein-RNA

Method

X-ray (2.44 Å)

Summary

Pp7 coat protein dimer in complex with RNA hairpin

Reference

Chao JA, Patskovsky Y, Almo SC, Singer RH (2008): "Structural basis for the coevolution of a viral RNA-protein complex." Nat.Struct.Mol.Biol., 15, 103-105. doi: 10.1038/nsmb1327.

Abstract

The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved beta-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.