SNAP output for PDB entry 2wq6 [SNAP web server]

PDB-id

2wq6; SNAP-derived features in text and JSON formats; DNAproDB

Class

lyase-DNA

Method

X-ray (2.3 Å)

Summary

Structure of the 6-4 photolyase of d. melanogaster in complex with the non-natural n4-methyl t(dewar)c lesion

Reference

Glas AF, Kaya E, Schneider S, Heil K, Fazio D, Maul MJ, Carell T (2010): "DNA (6-4) Photolyases Reduce Dewar Isomers for Isomerization Into (6-4) Lesions." J.Am.Chem.Soc., 132, 3254. doi: 10.1021/JA910917F.

Abstract

Repair of the Dewar valence isomers by (6-4) photolyases proceeds via an enzyme catalyzed ring-opening reaction of the Dewar lesion to the (6-4) photoproduct.