Summary information and primary citation

PDB-id
3b6g; SNAP-derived features in text and JSON formats; DNAproDB
Class
structural protein-DNA
Method
X-ray (3.45 Å)
Summary
Nucleosome core particle treated with oxaliplatin
Reference
Wu B, Droge P, Davey CA (2008): "Site selectivity of platinum anticancer therapeutics." Nat.Chem.Biol., 4, 110-112. doi: 10.1038/nchembio.2007.58.
Abstract
X-ray crystallographic and biochemical investigation of the reaction of cisplatin and oxaliplatin with nucleosome core particle and naked DNA reveals that histone octamer association can modulate DNA platination. Adduct formation also occurs at specific histone methionine residues, which could serve as a nuclear platinum reservoir influencing adduct transfer to DNA. Our findings suggest that the nucleosome center may provide a favorable target for the design of improved platinum anticancer drugs.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js