Summary information and primary citation
- PDB-id
- 3cxc; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- ribosome
- Method
- X-ray (3.0 Å)
- Summary
- The structure of an enhanced oxazolidinone inhibitor bound to the 50s ribosomal subunit of h. marismortui
- Reference
- Zhou J, Bhattacharjee A, Chen S, Chen Y, Duffy E, Farmer J, Goldberg J, Hanselmann R, Ippolito JA, Lou R, Orbin A, Oyelere A, Salvino J, Springer D, Tran J, Wang D, Wu Y, Johnson G (2008): "Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics." Bioorg.Med.Chem.Lett., 18, 6175-6178. doi: 10.1016/j.bmcl.2008.10.011.
- Abstract
- We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.
