SNAP output for PDB entry 3i55 [SNAP web server]

PDB-id

3i55; SNAP-derived features in text and JSON formats; DNAproDB

Class

ribosome-antibiotic

Method

X-ray (3.11 Å)

Summary

Co-crystal structure of mycalamide a bound to the large ribosomal subunit

Reference

Gurel G, Blaha G, Steitz TA, Moore PB (2009): "Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui." Antimicrob.Agents Chemother., 53, 5010-5014. doi: 10.1128/AAC.00817-09.

Abstract

Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the nascent peptide chain. Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs.