Summary information and primary citation
- PDB-id
- 3n6s; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transcription, replication-DNA
- Method
- X-ray (3.1 Å)
- Summary
- Crystal structure of human mitochondrial mterf in complex with a 15-mer DNA encompassing the trnaleu(uur) binding sequence
- Reference
- Jimenez-Menendez N, Fernandez-Millan P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernado P, Coll M, Uson I, Sola M (2010): "Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat." Nat.Struct.Mol.Biol., 17, 891-893. doi: 10.1038/nsmb.1859.
- Abstract
- The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.
