SNAP output for PDB entry 3n7q [SNAP web server]

PDB-id

3n7q; SNAP-derived features in text and JSON formats; DNAproDB

Class

transcription, replication-DNA

Method

X-ray (2.4 Å)

Summary

Crystal structure of human mitochondrial mterf fragment (aa 99-399) in complex with a 12-mer DNA encompassing the trnaleu(uur) binding sequence

Reference

Jimenez-Menendez N, Fernandez-Millan P, Rubio-Cosials A, Arnan C, Montoya J, Jacobs HT, Bernado P, Coll M, Uson I, Sola M (2010): "Human mitochondrial mTERF wraps around DNA through a left-handed superhelical tandem repeat." Nat.Struct.Mol.Biol., 17, 891-893. doi: 10.1038/nsmb.1859.

Abstract

The regulation of mitochondrial DNA (mtDNA) processes is slowly being characterized at a structural level. We present here crystal structures of human mitochondrial regulator mTERF, a transcription termination factor also implicated in replication pausing, in complex with double-stranded DNA oligonucleotides containing the tRNA(Leu)(UUR) gene sequence. mTERF comprises nine left-handed helical tandem repeats that form a left-handed superhelix, the Zurdo domain.