Summary information and primary citation
- PDB-id
- 3tfs; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transferase-DNA
- Method
- X-ray (2.0 Å)
- Summary
- Ternary complex structure of DNA polymerase beta with a gapped DNA substrate and a, b damp(cfh)pp in the active site: stereoselective binding of (s) isomer
- Reference
- Chamberlain BT, Batra VK, Beard WA, Kadina AP, Shock DD, Kashemirov BA, McKenna CE, Goodman MF, Wilson SH (2012): "Stereospecific Formation of a Ternary Complex of (S)-alpha, beta-Fluoromethylene-dATP with DNA Pol beta." Chembiochem, 13, 528-530. doi: 10.1002/cbic.201100738.
- Abstract
- The influence of water: crystallization of (R/S)-α,β-CHF-dATP with the preorganized pol β-DNA complex shows that (S)-α,β-CHF-dATP is preferentially bound to the active site with the C=F fluorine proximal to a structural water bound to Asp276.
