Summary information and primary citation
- PDB-id
- 3v6j; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transferase-DNA
- Method
- X-ray (2.3 Å)
- Summary
- Replication of n2,3-ethenoguanine by DNA polymerases
- Reference
- Zhao L, Christov PP, Kozekov ID, Pence MG, Pallan PS, Rizzo CJ, Egli M, Guengerich FP (2012): "Replication of n(2) ,3-ethenoguanine by DNA polymerases." Angew.Chem.Int.Ed.Engl., 51, 5466-5469. doi: 10.1002/anie.201109004.
- Abstract
- Damaged goods: The unstable DNA adduct N(2) ,3-ethenoguanine, a product of both exposure to the carcinogen vinyl chloride and of oxidative stress, was built into an oligonucleotide, using an isostere strategy to stabilize the glycosidic bond. This modification was then used to examine the cause of mutations by DNA polymerases, in terms of both the biochemistry of the lesion and a structure of the lesion within a polymerase.
