Summary information and primary citation
- PDB-id
- 4elu; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transferase-DNA
- Method
- X-ray (1.8 Å)
- Summary
- Snapshot of the large fragment of DNA polymerase i from thermus aquaticus processing modified pyrimidines
- Reference
- Obeid S, Busskamp H, Welte W, Diederichs K, Marx A (2012): "Interactions of non-polar and "Click-able" nucleotides in the confines of a DNA polymerase active site." Chem.Commun.(Camb.), 48, 8320-8322. doi: 10.1039/c2cc34181f.
- Abstract
- Modified nucleotides play a paramount role in many cutting-edge biomolecular techniques. The present structural study highlights the plasticity and flexibility of the active site of a DNA polymerase while incorporating non-polar "Click-able" nucleotide analogs and emphasizes new insights into rational design guidelines for modified nucleotides.
