Summary information and primary citation
- PDB-id
- 4uqg; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- transferase-DNA
- Method
- X-ray (2.0 Å)
- Summary
- A new bio-isosteric base pair based on reversible bonding
- Reference
- Tomas-Gamasa M, Serdjukow S, Su M, Muller M, Carell T (2015): ""Post-it" type connected DNA created with a reversible covalent cross-link." Angew. Chem. Int. Ed. Engl., 54, 796-800. doi: 10.1002/anie.201407854.
- Abstract
- We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.
