Summary information and primary citation

PDB-id
4wfb; SNAP-derived features in text and JSON formats; DNAproDB
Class
ribosome
Method
X-ray (3.43 Å)
Summary
The crystal structure of the large ribosomal subunit of staphylococcus aureus in complex with bc-3205
Reference
Eyal Z, Matzov D, Krupkin M, Wekselman I, Paukner S, Zimmerman E, Rozenberg H, Bashan A, Yonath A (2015): "Structural insights into species-specific features of the ribosome from the pathogen Staphylococcus aureus." Proc.Natl.Acad.Sci.USA, 112, E5805-E5814. doi: 10.1073/pnas.1517952112.
Abstract
The emergence of bacterial multidrug resistance to antibiotics threatens to cause regression to the preantibiotic era. Here we present the crystal structure of the large ribosomal subunit from Staphylococcus aureus, a versatile Gram-positive aggressive pathogen, and its complexes with the known antibiotics linezolid and telithromycin, as well as with a new, highly potent pleuromutilin derivative, BC-3205. These crystal structures shed light on specific structural motifs of the S. aureus ribosome and the binding modes of the aforementioned antibiotics. Moreover, by analyzing the ribosome structure and comparing it with those of nonpathogenic bacterial models, we identified some unique internal and peripheral structural motifs that may be potential candidates for improving known antibiotics and for use in the design of selective antibiotic drugs against S. aureus.

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