Summary information and primary citation

PDB-id
5yej; SNAP-derived features in text and JSON formats; DNAproDB
Class
DNA binding protein-DNA
Method
X-ray (2.698 Å)
Summary
Crystal structure of bioq with its naturel double-stranded DNA operator
Reference
Yan L, Tang Q, Guan Z, Pei K, Zou T, He J (2018): "Structural insights into operator recognition by BioQ in the Mycobacterium smegmatis biotin synthesis pathway." Biochim Biophys Acta Gen Subj, 1862, 1843-1851. doi: 10.1016/j.bbagen.2018.05.015.
Abstract
Background: Biotin is an essential cofactor in living organisms. The TetR family transcriptional regulator (TFTR) BioQ is the main regulator of biotin synthesis in Mycobacterium smegmatis. BioQ represses the expression of its target genes by binding to a conserved palindromic DNA sequence (the BioQ operator). However, the mechanism by which BioQ recognizes this DNA element has not yet been fully elucidated.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js