Summary information and primary citation

PDB-id
6dsv; SNAP-derived features in text and JSON formats; DNAproDB
Class
transferase-DNA
Method
X-ray (1.99 Å)
Summary
Bst DNA polymerase i post-chemistry (n+2) structure
Reference
Chim N, Jackson LN, Trinh AM, Chaput JC (2018): "Crystal structures of DNA polymerase I capture novel intermediates in the DNA synthesis pathway." Elife, 7. doi: 10.7554/eLife.40444.
Abstract
High resolution crystal structures of DNA polymerase intermediates are needed to study the mechanism of DNA synthesis in cells. Here we report five crystal structures of DNA polymerase I that capture new conformations for the polymerase translocation and nucleotide pre-insertion steps in the DNA synthesis pathway. We suggest that these new structures, along with previously solved structures, highlight the dynamic nature of the finger subdomain in the enzyme active site.

Cartoon-block schematics in six views (download the tarball)

PyMOL session file Download PDB file View in 3Dmol.js