SNAP output for PDB entry 6y42 [SNAP web server]

PDB-id

6y42; SNAP-derived features in text and JSON formats; DNAproDB

Class

transcription

Method

X-ray (4.3 Å)

Summary

Crystal structure of rsrr complexed to a 39 basepair DNA fragment of the rsrr promoter

Reference

Crack JC, Amara P, Volbeda A, Mouesca JM, Rohac R, Pellicer Martinez MT, Huang CY, Gigarel O, Rinaldi C, Le Brun NE, Fontecilla-Camps JC (2020): "Electron and Proton Transfers Modulate DNA Binding by the Transcription Regulator RsrR." J.Am.Chem.Soc., 142, 5104-5116. doi: 10.1021/jacs.9b12250.

Abstract

The [Fe₂S₂]-RsrR gene transcription regulator senses the redox status in bacteria by modulating DNA binding, while its cluster cycles between +1 and +2 states-only the latter binds DNA. We have previously shown that RsrR can undergo remarkable conformational changes involving a 100° rotation of tryptophan 9 between exposed (