SNAP output for PDB entry 6zot [SNAP web server]

PDB-id

6zot; SNAP-derived features in text and JSON formats; DNAproDB

Class

RNA binding protein

Method

X-ray (2.7 Å)

Summary

Crystal structure of ythdf3 yth domain in complex with m6a RNA

Reference

Li Y, Bedi RK, Moroz-Omori EV, Caflisch A (2020): "Structural and Dynamic Insights into Redundant Function of YTHDF Proteins." J.Chem.Inf.Model., 60, 5932-5935. doi: 10.1021/acs.jcim.0c01029.

Abstract

Three YTH-domain family proteins (YTHDF1, YTHDF2, and YTHDF3) recognize the N₆-methyladenosine (m₆A) modification of mRNA in cells. However, the redundancy of their cellular functions has been disputed. We investigate their interactions with m₆A-containing RNA using X-ray crystallography and molecular dynamics (MD). The new X-ray structures and MD simulations show that the three proteins share identical interactions with the m₆A-containing RNA and have similar intrinsic plasticity, thus evidencing the redundant roles of the three proteins in cellular functions.