Summary information and primary citation
- PDB-id
- 7fvs; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- isomerase
- Method
- X-ray (2.16 Å)
- Summary
- Crystal structure of s. aureus gyrase in complex with 4-[[1-[(1-chloro-6,7-dihydro-5h-cyclopenta[c]pyridin-6-yl)methyl]azetidin-3-yl]methylamino]-6-fluorochromen-2-one
- Reference
- Cumming JG, Kreis L, Kuhne H, Wermuth R, Vercruysse M, Kramer C, Rudolph MG, Xu Z (2023): "Discovery of a Series of Indane-Containing NBTIs with Activity against Multidrug-Resistant Gram-Negative Pathogens." Acs Med.Chem.Lett., 14, 993-998. doi: 10.1021/acsmedchemlett.3c00187.
- Abstract
- The rise of multidrug-resistant (MDR) Gram-negative bacteria is a major global health problem necessitating the discovery of new classes of antibiotics. Novel bacterial topoisomerase inhibitors (NBTIs) target the clinically validated bacterial type II topoisomerases with a distinct binding site and mechanism of action to fluoroquinolone antibiotics, thus avoiding cross-resistance to this drug class. Here we report the discovery of a series of NBTIs incorporating a novel indane DNA binding moiety. X-ray cocrystal structures of compounds
