SNAP output for PDB entry 7lsk [SNAP web server]

PDB-id

7lsk; SNAP-derived features in text and JSON formats; DNAproDB

Class

transferase-DNA

Method

X-ray (2.7 Å)

Summary

Structure of hiv-1 reverse transcriptase in complex with DNA, l-dttp, and ca(2+) ion

Reference

Ruiz FX, Hoang A, Dilmore CR, DeStefano JJ, Arnold E (2022): "Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing." Drug Discov Today, 27, 1832-1846. doi: 10.1016/j.drudis.2022.02.016.

Abstract

Infection with HIV can cripple the immune system and lead to AIDS. Hepatitis B virus (HBV) is a hepadnavirus that causes human liver diseases. Both pathogens are major public health problems affecting millions of people worldwide. The polymerases from both viruses are the most common drug target for viral inhibition, sharing common architecture at their active sites. The L-nucleoside drugs emtricitabine and lamivudine are widely used HIV reverse transcriptase (RT) and HBV polymerase (Pol) inhibitors. Nevertheless, structural details of their binding to RT(Pol)/nucleic acid remained unknown until recently. Here, we discuss the implications of these structures, alongside related complexes with L-dNTPs, for the development of novel L-nucleos(t)ide drugs, and prospects for repurposing them.