SNAP output for PDB entry 7lv8 [SNAP web server]

PDB-id

7lv8; SNAP-derived features in text and JSON formats; DNAproDB

Class

structural protein-DNA

Method

cryo-EM (3.4 Å)

Summary

Structure of the marseillevirus nucleosome

Reference

Valencia-Sanchez MI, Abini-Agbomson S, Wang M, Lee R, Vasilyev N, Zhang J, De Ioannes P, La Scola B, Talbert P, Henikoff S, Nudler E, Erives A, Armache KJ (2021): "The structure of a virus-encoded nucleosome." Nat.Struct.Mol.Biol., 28, 413-417. doi: 10.1038/s41594-021-00585-7.

Abstract

Certain large DNA viruses, including those in the Marseilleviridae family, encode histones. Here we show that fused histone pairs Hβ-Hα and Hδ-Hγ from Marseillevirus are structurally analogous to the eukaryotic histone pairs H2B-H2A and H4-H3. These viral histones form 'forced' heterodimers, and a heterotetramer of four such heterodimers assembles DNA to form structures virtually identical to canonical eukaryotic nucleosomes.