SNAP output for PDB entry 7m4v [SNAP web server]

PDB-id

7m4v; SNAP-derived features in text and JSON formats; DNAproDB

Class

ribosome

Method

cryo-EM (2.54 Å)

Summary

A. baumannii ribosome-eravacycline complex: 50s

Reference

Zhang Z, Morgan CE, Bonomo RA, Yu EW (2021): "Cryo-EM Determination of Eravacycline-Bound Structures of the Ribosome and the Multidrug Efflux Pump AdeJ of Acinetobacter baumannii." Mbio, 12, e0103121. doi: 10.1128/mBio.01031-21.

Abstract

Antibiotic-resistant strains of the Gram-negative pathogen Acinetobacter baumannii have emerged as a significant global health threat. One successful therapeutic option to treat bacterial infections has been to target the bacterial ribosome. However, in many cases, multidrug efflux pumps within the bacterium recognize and extrude these clinically important antibiotics designed to inhibit the protein synthesis function of the bacterial ribosome. Thus, multidrug efflux within A. baumannii and other highly drug-resistant strains is a major cause of failure of drug-based treatments of infectious diseases. We here report the first structures of the