Summary information and primary citation
- PDB-id
- 7w7l; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- DNA binding protein-DNA-DNA
- Method
- X-ray (3.0 Å)
- Summary
- Structure of nf-kb p52 homodimer bound to 13-mer a-t-centric p-selectin kb DNA fragment
- Reference
- Pan W, Meshcheryakov VA, Li T, Wang Y, Ghosh G, Wang VY (2023): "Structures of NF-kappa B p52 homodimer-DNA complexes rationalize binding mechanisms and transcription activation." Elife, 12. doi: 10.7554/eLife.86258.
- Abstract
- The mammalian NF-κB p52:p52 homodimer together with its cofactor Bcl3 activates transcription of κB sites with a central G/C base pair (bp), while it is inactive toward κB sites with a central A/T bp. To understand the molecular basis for this unique property of p52, we have determined the crystal structures of recombinant human p52 protein in complex with a P-selectin(PSel)-κB DNA (5'-GGGGT
