Summary information and primary citation
- PDB-id
- 8du4; SNAP-derived features in text and JSON formats;
DNAproDB
- Class
- DNA binding protein
- Method
- cryo-EM (3.55 Å)
- Summary
- Complex between rbbp5-wdr5 and an h2b-ubiquitinated nucleosome
- Reference
- Rahman S, Hoffmann NA, Worden EJ, Smith ML, Namitz KEW, Knutson BA, Cosgrove MS, Wolberger C (2022): "Multistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome." Proc.Natl.Acad.Sci.USA, 119, e2205691119. doi: 10.1073/pnas.2205691119.
- Abstract
- The human Mixed Lineage Leukemia-1 (MLL1) complex methylates histone H3K4 to promote transcription and is stimulated by monoubiquitination of histone H2B. Recent structures of the MLL1-WRAD core complex, which comprises the MLL1 methyltransferase,
